Pruritis is a common—and troublesome—side effect of opioids, often experienced by hospice patients. At Washington University’s Center for the Study of Itch, researchers have been studying mice models to better understand opioid-induced pruritis.
Investigators have discovered that a particular variant of the mu-opioid receptor (MOR) in the spinal cord called MOR1D specifically controls pruritis. When they blocked MOR1D in the spinal cord of mice, they were able to block morphine-induced pruritis without affecting morphine’s analgesic effect. In fact, analgesia appears to be mediated through a completely different spinal cord receptor, MOR1. In mice, blocking MOR1 eliminated analgesia, but not pruritis.
Dr. Zhou-Feng Chen, PhD, the principal investigator and director of Washington University’s Center for the Study of Itch, proposed that additional variants of the mu-opioid receptor may mediate other common side opioid side effects, such as nausea, respiratory depression and constipation. Dr. Chen hopes that the center’s research will help generate novel therapies aimed at opioid-induced pruritis, and perhaps other side effects as well. This research may one day benefit our hospice patients.
Reference: Cell 2011;147:447-458.
|My wife and I used to work with Operation Greyhound and helped save a few abesud Greyhounds over the years before I was injured in an accident on my motorcycle. Though I had to quit, I still have a soft spot for any dog needing help. I donated $20 to Champ but the ChipIn site didn't work very well. I had to try 3x before it worked (and I am VERY computer/internet literate). I would hate to see you lose funds because of a setting somewhere and I wanted to let you know there might be a problem.I don't have a bunch of money so $20 is a lot to me. If you need more I have quite a few contacts and can help raise more. Let me know what you require. Good luck and please post updates on Champ's status.Jon
Posted 8/6/2012 12:22:17 AM
|First 10||<<Previous 10||Next 10 >>||Last 10|
Education Resources and Support for Hospices
Stay up-to-date on the latest hospice pharmacy benefits management information and tools with a variety of education resources and support at no extra charge. We offer presentations live at your facility, over the Internet or viateleconference, online service education programs, customized courses, and courses accredited for nursing continuing education credit.
Our palliative care experts provide clinical consulting on important medication management and care decisions. Our non-dispensing pharmacists provide focused attention and unbiased advice.
Why Use A PBM?
Contracting with multiple pharmacies, doing all the reporting, trying to stay current with medical practices and stay compliant while keeping costs down? There’s an easier and more effective way.